Differential Effects of Statins and Ezetimibe on Rho-Associated Coiled-Coil Containing Protein Kinase Activity, Endothelial Function, and Inflammation
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Copyright © 2008 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/CIRCULATIONAHA.108.813311 published online Dec 15, 2008; Circulation Ping-Yen Liu, Yen-Wen Liu, Li-Jen Lin, Jyh-Hong Chen and James K. Liao Endothelial Function, and Inflammation Ezetimibe on Rho-Associated Coiled-Coil Containing Protein Kinase Activity, Evidence for Statin Pleiotropy in Humans. Differential Effects of Statins and http://circ.ahajournals.org located on the World Wide Web at: The online version of this article, along with updated information and services, is
منابع مشابه
Rho-Associated Coiled-Coil Containing Protein Kinase Activity, Endothelial Function, Evidence for Statin Pleiotropy in Humans : Differential Effects of Statins and Ezetimibe
and Inflammation on Rho-Associated Coiled-Coil Containing Protein Kinase Activity, Endothelial Function, Evidence for Statin Pleiotropy in Humans : Differential Effects of Statins and Ezetimibe Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2008 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 752...
متن کاملEvidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation.
BACKGROUND By inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, statins not only reduce cholesterol biosynthesis but also decrease the formation of isoprenoids, which are important for mediating signaling through the Rho-associated coiled-coil containing protein kinase (ROCK) pathway. Increased ROCK activity has been implicated in endothelial dysfunction and vascular inflammation. We ...
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Background: Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial glands and stroma surrounded by dense fibrous tissue. Whereas, normal eutopic endometrium shows scarless tissue repair during menstrual cycles, which suggests that the endometriotic tissues have distinct mechanisms of fibrogenesis. During the development of en...
متن کاملBMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1.
OBJECTIVE In addition to lowering cholesterol, statins exert pleiotropic effects on endothelial cells. Bone morphogenetic proteins (BMPs) have recently been implicated in vascular inflammation and disease. We set out to investigate the effect of statins on BMP endothelial cell precursor-derived regulator (BMPER), a novel member of the BMP pathway. METHODS AND RESULTS Mevastatin enhanced BMPER...
متن کاملReduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
BACKGROUND Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse melanoma cell line. METHODS The cytotoxicity of statins toward the B16BL6 cells were evaluated u...
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تاریخ انتشار 2008